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Description

Sleep change is commonly reported in Alzheimer’s disease (AD) patients and their brain wave studies show decrease in dreaming and non-dreaming stages. Although sleep disturbance is generally considered as a consequence of AD, it might also be a risk factor of AD as new biological evidence shows. Leveraging the National Sleep Research Resource (NSRR), we built a unique cohort of 83 cases and 331 controls with clinical variables and electroencephalography (EEG) signals. Supervised tensor factorization method was applied for this temporal dataset to extract discriminative sleep patterns. Among the 30 patterns extracted, we identified 5 significant patterns (4 patterns for AD likely and 1 pattern for normal ones) and their visual patterns provide interesting linkage to sleep with repeated wakefulness, abnormal REM sleep, and insomnia. This study is preliminary but findings are interesting, which is a first step to provide quantifiable evidences to measure sleep as a risk factor of AD.

Learning Objective: Develop a computational framework to derive sleep patterns of Alzheimer's disease patients

Authors:

Yejin Kim (Presenter)
University of Texas Health Science Center at Houston

Xiaoqian Jiang, University of Texas Health Science Center at Houston
Luyao Chen, University of Texas Health Science Center at Houston
Xiaojin Li, Case Western Reserve University
Licong Cui, University of Texas Health Science Center at Houston

Presentation Materials:

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