Abstract Body: The NIH All of Us Research Program is a historic effort to gather data over many years from one million or more people living in the United States, with the ultimate goal of accelerating research and improving health. All of Us will serve as an international research resource, covering a wide variety of health conditions, with researchers using the data to learn more about how individual differences in lifestyle, environment, and biological makeup can influence health and disease. In the first year of enrollment, more than 180,000 participants have contributed biospecimens, answered surveys, and agreed to share their EHR. We have collected over 112,000 electronic health records (EHRs) from 34 healthcare provider organizations. About 80% of the core participants are from populations traditionally underrepresented in biomedical research. All of Us intends to sequence the genomes of one million people and, not only release these data to investigators, but also return genetic information with health relevance to individual participants who wish to receive it. The All of Us Research Hub will open to investigators in the Winter of 2019.

This session will 1) provide an overview of the All of Us Research Program and the status of recruiting a cohort of 1 million engaged participants, 2) provide an overview of data elements collected, including EHR data, and their curation, 3) describe the genomics plan, including returning genomic results to participants, 4) describe the data protection strategies of the program, and 5) demonstrate use of the All of Us public data browser, the Researcher Workbench, and initial demonstration projects.


Joshua Denny (Presenter)
Vanderbilt University Medical Center

Mark Begale (Presenter)
Vibrent Health

Lucila Ohno-Machado (Presenter)
University of California San Diego

Kelly Gebo (Presenter)
National Institutes of Health

Robert Carroll (Presenter)
Vanderbilt University Medical Center

Bradley Malin (Presenter)
Vanderbilt University Medical Center

Andrea Ramirez (Presenter)
Vanderbilt University Medical Center

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