Genome-wide association studies (GWAS) are a hypothesis-free means to identify associations between genetic regions (loci) and characteristics (including diseases). These have been performed on thousands of patients with Alzheimer’s disease (AD) in order to find mutations that alter disease risk. In this work, we collect loci identified from GWAS and fine map each locus with the aim of identifying the likely causal variant and therefore understand the mechanisms of AD.

Authors:

Saloni Shah (Presenter)
Harker School