Dr. He is a tenured Associate Professor in the School of Information (iSchool) at the Florida State University and a Core Affiliate of the Institute for Successful Longevity. He is also holding courtesy appointments with Department of Behavioral Sciences and Social Medicine of College of Medicine and Department of Computer Science. At Florida State, he is BERD/Informatics Lead of the FSU-UF Clinical and Translational Science Award and Method Core Lead of the Center for Translational Behavioral Science. 

His research lies in biomedical and health informatics, clinical research informatics, data mining, knowledge representation, and big data analytics. The overarching goal of his research is to improve population health and advance biomedical research through the collection, analysis, and application of electronic health data from heterogeneous sources. As Principal Investigator, his research has been funded by National Institutes of Health, Eli Lilly and Company, Amazon, NVIDIA, FSU Council on Research and Creativity, and Institute for Successful Longevity.