Estimating drug exposures and defining their temporal relationship to drug response outcomes is challenged by incomplete prescription data and lack of reconciliation between drug exposure records. We devised a method to visualize all sources of medication data, including concept matched drug mentions, e-prescribing records, and manually curated drug lists, maintaining temporal relationships, and annotating with drug response phenotypes. The method has utility for empirically creating rules to define drug exposure epochs for each patient.

Learning Objective: Learn challenges and possible solutions for defining drug exposure in an environment lacking complete prescription data and reconciliation between drug exposure records.

Authors:

Andrea Ramirez (Presenter)
Vanderbilt University Medical Center

Yaping Shi, Vanderbilt University Medical Center
Elliot Fielstein, Vanderbilt University Medical Center
Jonathan Schildcrout, Vanderbilt University Medical Center
Henry Ong, Vanderbilt University Medical Center
Joshua Denny, Vanderbilt University Medical Center
Josh Peterson, Vanderbilt University Medical Center

Presentation Materials:

• Abstract/Manuscript - 1